RDoC Matrix

The Research Domain Criteria (RDoC) Matrix is a research framework, intended to break down mental illness into fundamental mental processes compared across biological and behavioral units. In this RDoC Matrix, rows represent specific dimensions of function (Domains and Constructs) and columns represent areas for study (Units of Analysis).

The initial development of the RDoC matrix was the collaborative effort of leading scientists across multiple workshops to articulate and define the knowledge for each of the five domains. Results from six workshops have identified five fundamental Domains, each associated with a set of Constructs and Sub-Constructs. Our current collection of research tools often reveal specific information about structure and function from the molecular level (e.g., genes, proteins) to the system level (e.g., circuits, behavior, paradigms); this broad scale is represented by "Units of Analysis" in the RDoC Matrix. The association of these Units of Analysis with specific Domains, Constructs, and Sub-Constructs forms a new research framework that is the basis for the RDoC Project.

The proceedings of these RDoC Workshops demonstrate the type of formative conversations that laid the foundation for each of the six constructs that comprise RDoC:

  • Working Memory Workshop Proceedings, July 2010 (HTML | PDF)
  • Negative Valence Systems Workshop Proceedings, March 2011 (HTML | PDF)
  • Positive Valence Systems Workshop Proceedings, June 2011 (HTML | PDF)
  • Cognitive Systems Workshop Proceedings, October 2011 (HTML | PDF)
  • Systems for Social Processes Workshop Proceedings, February 2012 (HTML | PDF)
  • Arousal/Regulatory Systems Workshop Proceedings, June 2012 (HTML | PDF)

A list of the terms utilized in the RDoC Matrix can be found in our Definitions of Constructs section.

More information can be found on the NIMH website for the Research Domain Criteria (RDoC) Project.